Manganese-enhanced MRI in the evaluation of cell-based therapy for myocardial restoration
نویسندگان
چکیده
Background To date, the underlying mechanism responsible for the restoration of the injured myocardium following transplantation of stem cells has not been clearly identified. Three major hypotheses have been previously proposed: cardiac differentiation of transplanted cells (de novo myocardial regeneration), paracrine effect on existing myocardium (myocardial salvage) or recruitment of cardiac progenitor cells. Manganese-enhanced MRI (MEMRI) has recently been published as a reliable method of imaging viable myocardium (Dash et al 2011). Utilizing MEMRI, we evaluated the changes in the viability of the injured myocardium to further investigate the underlying mechanism of functional restoration using stem cell therapy.
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RATIONALE The mechanism of functional restoration by stem cell therapy remains poorly understood. Novel manganese-enhanced MRI and bioluminescence reporter gene imaging were applied to follow myocardial viability and cell engraftment, respectively. Human-placenta-derived amniotic mesenchymal stem cells (AMCs) demonstrate unique immunoregulatory and precardiac properties. In this study, the rest...
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